Starvation stress attenuates the miRNA-target interaction in suppressing breast cancer cell proliferation.

ABSTRACT:

Background

Emerging evidence has demonstrated the limited access to metabolic substrates as an effective approach to block cancer cell growth. The mechanisms remain unclear. Our previous work has revealed that miR-221/222 plays important role in regulating breast cancer development and progression through interaction with target gene p27.

Results

Herein, we determined the miRNA-mRNA interaction in breast cancer cells under induced stress status of starvation. Starvation stimulation attenuated the miR-221/222-p27 interaction in MDA-MB-231 cells, thereby increased p27 expression and suppressed cell proliferation. Through overexpression or knockdown of miR-221/222, we found that starvation-induced stress attenuated the negative regulation of p27 expression by miR-221/222. Simil

SUBMITTER: Lu J 

PROVIDER: S-EPMC7339532 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature