Maternal obesity alters C19MC microRNAs expression profile in fetal umbilical cord blood.

ABSTRACT: Background:To determine if overweight/obese pregnant women have altered microRNA expression patterns in fetal umbilical cord blood that may affect the development of offspring. Methods:Umbilical cord blood samples were obtained from the fetuses of 34 overweight/obese and 32 normal-weight women after delivery. Next generation sequencing (NGS) analyzed their miRNA expression patterns. miRanda and TargetScan databases were used to predict the miRNAs' target genes followed by analyses of Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) to perform function grouping and pathway analyses. qRT-PCR verified the identity of differentially expressed miRNAs that were revealed in the NGS results. Results:There was a positive correlation between newborn body weight and pregestational BMI of pregnant individuals (r?=?0.48, P?

SUBMITTER: Jing J 

PROVIDER: S-EPMC7339545 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature