Comparative whole genome DNA methylation profiling across cattle tissues reveals global and tissue-specific methylation patterns.

ABSTRACT:

Background

Efforts to improve animal health, and understand genetic bases for production, may benefit from a comprehensive analysis of animal genomes and epigenomes. Although DNA methylation has been well studied in humans and other model species, its distribution patterns and regulatory impacts in cattle are still largely unknown. Here, we present the largest collection of cattle DNA methylation epigenomic data to date.

Results

Using Holstein cattle, we generated 29 whole genome bisulfite sequencing (WGBS) datasets for 16 tissues, 47 corresponding RNA-seq datasets, and 2 whole genome sequencing datasets. We did read mapping and DNA methylation calling based on two different cattle assemblies, demonstrating the high quality of the long-read-based assembly markedly improved D

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC7339546 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature