Decoding the differentiation of mesenchymal stem cells into mesangial cells at the transcriptomic level.

ABSTRACT:

Background

Mesangial cells play an important role in the glomerulus to provide mechanical support and maintaine efficient ultrafiltration of renal plasma. Loss of mesangial cells due to pathologic conditions may lead to impaired renal function. Mesenchymal stem cells (MSC) can differentiate into many cell types, including mesangial cells. However transcriptomic profiling during MSC differentiation into mesangial cells had not been studied yet. The aim of this study is to examine the pattern of transcriptomic changes during MSC differentiation into mesangial cells, to understand the involvement of transcription factor (TF) along the differentiation process, and finally to elucidate the relationship among TF-TF and TF-key gene or biomarkers during the differentiation of MSC into mesa

SUBMITTER: Wong CY 

PROVIDER: S-EPMC7339572 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature