MiR‑29 mediates exercise‑induced skeletal muscle angiogenesis by targeting VEGFA, COL4A1 and COL4A2 via the PI3K/Akt signaling pathway.

ABSTRACT: The present study investigated the molecular changes and related regulatory mechanisms in the response of skeletal muscle to exercise. The microarray dataset 'GSE109657' of the skeletal muscle response to high‑intensity intermittent exercise training (HIIT) was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were screened and analyzed using weighted gene co‑expression network analysis (WGCNA) to identify the significant functional co‑expressed gene modules. Moreover, functional enrichment analysis was performed for the DEGs in the significant modules. In addition, protein‑protein interaction (PPI) network and microRNA (miR)‑transcription factor (TF)‑target regulatory network were constructed. A total of 530 DEGs in the skeletal muscle were screen

SUBMITTER: Chen L 

PROVIDER: S-EPMC7339600 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature