LncRNA MALAT1 modulates cancer stem cell properties of liver cancer cells by regulating YAP1 expression via miR‑375 sponging.

ABSTRACT: Liver cancer stem cells (CSCs) are functionally defined by their ability to undergo self‑renewal, and may contribute to metastasis, recurrence and drug resistance in liver cancer. The long non‑coding RNA metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) has been implicated in tumor formation and metastasis of liver cancer. However, the exact mechanism by which MALAT1 modulates liver CSC features remains largely unknown. In the present study, the expression level of MALAT1 was elevated in cancer spheroids compared with the corresponding levels noted in parental liver cancer cells, whereas the suppression of MALAT1 resulted in markedly reduced sphere formation and decreased expression of stemness factors in liver cancer cells. Dual‑luciferase assay and RNA pull‑down assays furt

SUBMITTER: Zhao L 

PROVIDER: S-EPMC7339611 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature