Echinacoside promotes the proliferation of human renal tubular epithelial cells by blocking the HBX/TREM2‑mediated NF‑κB signalling pathway.

ABSTRACT: Hepatitis B virus X (HBX) protein is required for the replication of HBV and plays a role in the progression of hepatitis in humans. However, the underlying function of HBX during HBV‑induced chronic glomerulonephritis (HBV‑GN) is unknown. Echinacoside (ECH) is a phenylethanoid glycoside from the Cistanche genus, which possesses strong antiapoptosis and neuroprotective activities. In the present study, the function of HBX and the relationship between HBX and ECH in human renal tubular epithelial cells (RTECs; HK‑2 cell line) were explored. Reverse transcription‑quantitative PCR and western blot analyses were used to quantify the mRNA and protein expression levels of HBX in HK‑2 cells, respectively. The Cell Counting Kit‑8 assay was performed to analyse cell proliferation. Flow cytometry an

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7339676 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature