Molecular mechanism of gossypol mediating CCL2 and IL‑8 attenuation in triple‑negative breast cancer cells.

ABSTRACT: Chronic inflammation associated with cancer is characterized by the production of different types of chemokines and cytokines. In cancer, numerous signaling pathways upregulate the expression levels of several cytokines and evolve cells to the neoplastic state. Therefore, targeting these signaling pathways through the inhibition of distinctive gene expression is a primary target for cancer therapy. The present study investigated the anticancer effects of the natural polyphenol gossypol (GOSS) in triple‑negative breast cancer (TNBC) cells, the most aggressive breast cancer type with poor prognosis. GOSS effects were examined in two TNBC cell lines: MDA‑MB‑231 (MM‑231) and MDA‑MB‑468 (MM‑468), representing Caucasian Americans (CA) and African Americans (AA), respectively. The obtained IC50s

SUBMITTER: Messeha SS 

PROVIDER: S-EPMC7339712 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature