Polymer-Based Bioorthogonal Nanocatalysts for the Treatment of Bacterial Biofilms.

ABSTRACT: Bioorthogonal catalysis offers a unique strategy to modulate biological processes through the in situ generation of therapeutic agents. However, the direct application of bioorthogonal transition metal catalysts (TMCs) in complex media poses numerous challenges due to issues of limited biocompatibility, poor water solubility, and catalyst deactivation in biological environments. We report here the creation of catalytic "polyzymes", comprised of self-assembled polymer nanoparticles engineered to encapsulate lipophilic TMCs. The incorporation of catalysts into these nanoparticle scaffolds creates water-soluble constructs that provide a protective environment for the catalyst. The potential therapeutic utility of these nanozymes was demonstrated through antimicrobial studies in which a cation

SUBMITTER: Huang R 

PROVIDER: S-EPMC7339739 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature