Schizophrenia‑associated microRNA‑148b‑3p regulates COMT and PRSS16 expression by targeting the ZNF804A gene in human neuroblastoma cells.

ABSTRACT: Zinc finger protein 804A (ZNF804A) has been identified by genome‑wide association studies as a robust risk gene in schizophrenia, but how ZNF804A contributes to schizophrenia and its upstream regulation remains unknown. Previous studies have indicated that microRNAs (miRs) are key factors that regulate the expression levels of their target genes. The present study revealed significantly increased expression of miR‑148b‑3p in the peripheral blood of patients with first‑onset schizophrenia compared with healthy controls, and bioinformatics analysis predicted that the ZNF804A gene is a target of miR‑148b‑3p. Therefore, the present study investigated the possible upstream regulation of ZNF804A by miR‑148b‑3p in the human neuroblastoma SH‑SY5Y cell line, and assessed the implications for schizo

SUBMITTER: Wu S 

PROVIDER: S-EPMC7339789 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature