Tumour response 3 months after neoadjuvant single-fraction radiotherapy for low-risk breast cancer.

ABSTRACT:

Introduction

Standard treatment for early-stage invasive breast cancer (bca) consists of breast-conserving surgery and several weeks of adjuvant radiotherapy (rt). Neoadjuvant single-fraction rt is a novel approach for early-stage bca. We sought to investigate the effect of delaying surgery after neoadjuvant rt with respect to the rate of pathologic response (pr).

Methods

Women 65 years of age or older with a new diagnosis of stage i luminal A bca were eligible for inclusion. A single 20 Gy dose to the primary breast tumour was given, followed by breast-conserving surgery 3 months later. The primary endpoint was the pr rate assessed by microscopic evaluation using the Miller-Payne system.

Results

To date, 10 patients have been successfully treated. Median age of the p

SUBMITTER: Tiberi D 

PROVIDER: S-EPMC7339847 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature