Effect of oxygen fraction on airway rescue: a computational modelling study.

ABSTRACT:

Background

During induction of general anaesthesia, patients frequently experience apnoea, which can lead to dangerous hypoxaemia. An obstructed upper airway can impede attempts to provide ventilation. Although unrelieved apnoea is rare, it continues to cause deaths. Clinical investigation of management strategies for such scenarios is effectively impossible because of ethical and practical considerations.

Methods

A population-representative cohort of 100 virtual (in silico) subjects was configured using a high-fidelity computational model of the pulmonary and cardiovascular systems. Each subject breathed 100% oxygen for 3 min and then became apnoeic, with an obstructed upper airway, during induction of general anaesthesia. Apnoea continued throughout the protocol. When arte

SUBMITTER: Laviola M 

PROVIDER: S-EPMC7339872 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature