Increased chemotherapy-induced ovarian reserve loss in women with germline BRCA mutations due to oocyte deoxyribonucleic acid double strand break repair deficiency.

ABSTRACT:

Objective

To assess whether woman who have BRCA mutations (WBM) experience more declines in ovarian reserve after chemotherapy treatment, as it induces oocyte death by deoxyribonucleic acid (DNA) damage, and BRCA mutations result in DNA damage repair deficiency.

Design

Longitudinal cohort study.

Setting

Academic centers.

Patient(s)

The 108 evaluable women with breast cancer were stratified into those never tested (negative family history; n = 35) and those negative (n = 59) or positive (n = 14) for a pathogenic BRCA mutation.

Intervention(s)

Sera were longitudinally obtained before and 12-24 months after chemotherapy treatment, assayed for antimüllerian hormone (AMH), and adjusted for age at sample collection.

Main outcome measure(s)

Ovarian recov

SUBMITTER: Oktay KH 

PROVIDER: S-EPMC7339936 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature