Helios enhances the preferential differentiation of human fetal CD4⁺ naive T cells into regulatory T cells.

ABSTRACT: T cell receptor (TCR) stimulation and cytokine cues drive the differentiation of CD4⁺ naïve T cells into effector T cell populations with distinct proinflammatory or regulatory functions. Unlike adult naïve T cells, human fetal naïve CD4⁺ T cells preferentially differentiate into FOXP3⁺ regulatory T (T_reg) cells upon TCR activation independent of exogenous cytokine signaling. This cell-intrinsic predisposition for T_reg differentiation is implicated in the generation of tolerance in utero; however, the underlying mechanisms remain largely unknown. Here, we identify epigenetic and transcriptional programs shared between fetal naïve T and committed T_reg cells that are inactive in adult naïve T cells and show that fetal-derived

SUBMITTER: Ng MSF 

PROVIDER: S-EPMC7340007 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature