Collagen Turnover in Relation to Risk Factors and Hemodynamics in Human Intracranial Aneurysms.

ABSTRACT: Background and Purpose- Determinants for molecular and structural instability, that is, impending growth or rupture, of intracranial aneurysms (IAs) remain uncertain. To elucidate this, we endeavored to estimate the actual turnover rates of the main molecular constituent in human IA (collagen) on the basis of radiocarbon (¹⁴C) birth dating in relation to IA hemodynamics. Methods- Collagen turnover rates in excised human IA samples were calculated using mathematical modeling of ¹⁴C birth dating data of collagen in relation to risk factors and histological markers for collagen maturity/turnover in selected IA. Hemodynamics were simulated using image-based computational fluid dynamics. Correlation, logistic regression, and receiver operating characteristic analyses were

SUBMITTER: Hackenberg KAM 

PROVIDER: S-EPMC7340076 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature