Broadly neutralizing antibodies for the treatment and prevention of HIV infection.

ABSTRACT:

Purpose of review

Several anti-HIV-1 broadly neutralizing antibodies (bNAbs) with exceptional breadth and potency, and targeting different HIV-1 envelope epitopes have entered clinical trials. bNAbs are being evaluated for their potential as long-acting alternatives to antiretrovirals in HIV-1 prevention and therapy, and for potential role in strategies aiming at long-term viral remission. Here, we discuss recent findings from bNAb clinical studies.

Recent findings

bNAbs targeting distinct HIV-1 envelope epitopes have shown, in general, favorable safety profiles, and engineered bNAb variants have demonstrated improved pharmacokinetics. Single bNAb infusions transiently decreased viremia with subsequent selection of escape variants, while a combination of two bNAbs successful

SUBMITTER: Caskey M 

PROVIDER: S-EPMC7340121 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature