Aberrant sorting of hippocampal complex pyramidal cells in type I lissencephaly alters topological innervation.

ABSTRACT: Layering has been a long-appreciated feature of higher order mammalian brain structures but the extent to which it plays an instructive role in synaptic specification remains unknown. Here we examine the formation of synaptic circuitry under cellular heterotopia in hippocampal CA1, using a mouse model of the human neurodevelopmental disorder Type I Lissencephaly. We identify calbindin-expressing principal cells which are mispositioned under cellular heterotopia. Ectopic calbindin-expressing principal cells develop relatively normal morphological features and stunted intrinsic physiological features. Regarding network development, a connectivity preference for cholecystokinin-expressing interneurons to target calbindin-expressing principal cells is diminished. Moreover, in vitro gamma oscil

SUBMITTER: D'Amour JA 

PROVIDER: S-EPMC7340499 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature