Blood transcriptome analysis reveals gene expression features of breast-feeding rhesus macaque ( Macaca mulatta) infants.

ABSTRACT: During the breast-feeding period, infants undergo remarkable changes, including rapid physiological and developmental growth. However, little is known about gene expression features and sex-specific gene expression in breast-feeding infants. In this study, we sequenced 32 blood transcriptomes from 16 breast-feeding rhesus macaque ( Macaca mulatta) infants and their lactating mothers. We identified 218 differentially expressed genes (DEGs) between infants and mothers, including 91 up-regulated and 127 down-regulated DEGs in the infant group. Functional enrichment analysis of the up-regulated DEGs and unique hub genes in infants showed primary enrichment in immunity, growth, and development. Protein-protein interaction analysis also revealed that genes at key positions in infants were

SUBMITTER: Lan Y 

PROVIDER: S-EPMC7340523 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature