Age-associated changes in amyloid-β and formaldehyde concentrations in cerebrospinal fluid of rhesus monkeys.

ABSTRACT: Rhesus monkeys ( Macaca mulatta) are valuable experimental animals for studies on neurodegenerative diseases due to their evolutionarily close relationship to humans (Zhang et al., 2014). Rhesus monkeys also display similar hallmarks of aging and neurodegeneration as humans, including formation of senile plaques in the brain (Beckman et al., 2019; Paspalas et al., 2018). However, changes in formaldehyde (FA) levels in the cerebrospinal fluid (CSF) of rhesus monkeys with aging have not been reported. Additionally, whether changes in CSF FA are correlated with changes in amyloid-β (Aβ) concentrations have not yet been explored. Here, the CSF levels of Aβ ₄₀, Aβ ₄₂, and FA were measured in 56 rhesus monkeys of different ages, ranging from 4 to 26 years old. Result

SUBMITTER: Li ZH 

PROVIDER: S-EPMC7340526 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature