Real-time dynamics of <i>Plasmodium</i> NDC80 reveals unusual modes of chromosome segregation during parasite proliferation.

ABSTRACT: Eukaryotic cell proliferation requires chromosome replication and precise segregation to ensure daughter cells have identical genomic copies. Species of the genus Plasmodium, the causative agents of malaria, display remarkable aspects of nuclear division throughout their life cycle to meet some peculiar and unique challenges to DNA replication and chromosome segregation. The parasite undergoes atypical endomitosis and endoreduplication with an intact nuclear membrane and intranuclear mitotic spindle. To understand these diverse modes of Plasmodium cell division, we have studied the behaviour and composition of the outer kinetochore NDC80 complex, a key part of the mitotic apparatus that attaches the centromere of chromosomes to microtubules of the mitotic spindle. Using NDC80

SUBMITTER: Zeeshan M 

PROVIDER: S-EPMC7340582 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature