TNF-α G-308A genetic variants, serum CRP-hs concentration and DNA damage in obese women.

ABSTRACT: Obesity is associated with inflammation, which can disturb genome stability. Tumor necrosis factor (TNF-α) polymorphism was found to affect TNF-α protein production and inflammation. Therefore, the present study illustrates the relationship between TNF-α polymorphism, the degree of inflammation assessed by serum high sensitivity C-reactive protein concentration (CRP-hs) and basal DNA damage in patients with obesity (BMI 30-34.9 kg/m²) and control subjects with proper body mass (BMI < 25 kg/m²). A total of 115 participants (75 obese premenopausal women; and 40 age-, and gender-matched controls) were included. Biochemical parameters (serum concentrations of total-cholesterol, HDL-cholesterol, LDL- cholesterol, triglycerides, glucose, apolipoprotein AI, CRP-hs) and endog

SUBMITTER: Wlodarczyk M 

PROVIDER: S-EPMC7340642 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature