Stroke Induces Prolonged Changes in Lipid Metabolism, the Liver and Body Composition in Mice.

ABSTRACT: During recovery, stroke patients are at risk of developing long-term complications that impact quality of life, including changes in body weight and composition, depression and anxiety, as well as an increased risk of subsequent vascular events. The aetiologies and time-course of these post-stroke complications have not been extensively studied and are poorly understood. Therefore, we assessed long-term changes in body composition, metabolic markers and behaviour after middle cerebral artery occlusion in mice. These outcomes were also studied in the context of obesity, a common stroke co-morbidity proposed to protect against post-stroke weight loss in patients. We found that stroke induced long-term changes in body composition, characterised by a sustained loss of fat mass with a recovery

SUBMITTER: Haley MJ 

PROVIDER: S-EPMC7340675 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature