Dataset Information

Belimumab is a promising third-line treatment option for refractory autoimmune hepatitis.

ABSTRACT:

Background & aims

Autoimmune hepatitis (AIH) is a disease of unknown aetiology with a favourable response to immunosuppression. However, in the clinic, it appears that <50% of patients achieve complete response on standard treatment. Serum B cell-activating factor (BAFF) levels are elevated in patients with AIH and are likely to contribute to disease pathogenesis. Given that belimumab, a BAFF inhibitor, has been shown to be effective in other autoimmune diseases, we investigated its use as a third-line add-on treatment option in patients with advanced AIH who did not respond to conventional treatment.

Methods

Herein, we report for the first time two patients, a 27-year-old female and a 58-year-old male, both with AIH-related compensated cirrhosis at diagnosis, who were refractory to standard immunosuppressive therapies and received add-on third-line therapy with belimumab.

Results

Both patients achieved a complete response and remained in remission while receiving low-dose corticosteroids. No adverse events related to belimumab and/or disease decompensation were observed.

Conclusions

These preliminary findings indicate belimumab as a promising treatment option for patients with AIH and refractory and advanced liver-related fibrosis.

Lay summary

A small proportion of patients with autoimmune hepatitis (AIH) are refractory to standard treatments; these patients bear the highest probability of developing decompensated cirrhosis and hepatocellular carcinoma because third-line treatment options are not well established. In this case study, we showed that third-line add-on therapy with belimumab, a B cell-activating factor inhibitor, could be an alternative and promising treatment option in patients with advanced AIH who did not respond to conventional treatment.

SUBMITTER: Arvaniti P

PROVIDER: S-EPMC7340979 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Publications

Belimumab is a promising third-line treatment option for refractory autoimmune hepatitis.

Arvaniti Pinelopi P Giannoulis George G Gabeta Stella S Zachou Kalliopi K Koukoulis George K GK Dalekos George N GN

JHEP reports : innovation in hepatology 20200529 4

<h4>Background & aims</h4>Autoimmune hepatitis (AIH) is a disease of unknown aetiology with a favourable response to immunosuppression. However, in the clinic, it appears that <50% of patients achieve complete response on standard treatment. Serum B cell-activating factor (BAFF) levels are elevated in patients with AIH and are likely to contribute to disease pathogenesis. Given that belimumab, a BAFF inhibitor, has been shown to be effective in other autoimmune diseases, we investigated its use ...[more]

PMID: 32671332

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Dataset Information

Belimumab is a promising third-line treatment option for refractory autoimmune hepatitis.

Background & aims

Methods

Results

Conclusions

Lay summary

Publications

Belimumab is a promising third-line treatment option for refractory autoimmune hepatitis.

Similar Datasets

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