Fibrin sealant for esophageal anastomosis: A phase II study.

ABSTRACT:

Background

Esophagectomy is a pivotal curative modality for localized esophageal or esophagogastric junction cancer (EC or EJC). Postoperative anastomotic leakage (AL) remains problematic. The use of fibrin sealant (FS) may improve the strength of esophageal anastomosis and reduce the incidence of AL.

Aim

To assess the efficacy and safety of applying FS to prevent AL in patients with EC or EJC.

Methods

In this single-arm, phase II trial (Clinicaltrial.gov identifier: NCT03529266), we recruited patients aged 18-80 years with resectable EC or EJC clinically staged as T1-4aN0-3M0. An open or minimally invasive McKeown esophagectomy was performed with a circular stapled anastomosis. After performing the anastomosis, 2.5 mL of porcine FS was applied circumferentially. The

SUBMITTER: Lin YB 

PROVIDER: S-EPMC7340992 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature