Left Ventricular Hypertrophy and Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.

ABSTRACT: BACKGROUND AND PURPOSE:Left ventricular hypertrophy (LVH) is associated with the risk of stroke and dementia independently of other vascular risk factors, but its association with cerebral small vessel disease (CSVD) remains unknown. Here, we employed a systematic review and meta-analysis to address this gap. METHODS:Following the MOOSE guidelines (PROSPERO protocol: CRD42018110305), we systematically searched the literature for studies exploring the association between LVH or left ventricular (LV) mass, with neuroimaging markers of CSVD (lacunes, white matter hyperintensities [WMHs], cerebral microbleeds [CMBs]). We evaluated risk of bias and pooled association estimates with random-effects meta-analyses. RESULTS:We identified 31 studies (n=25,562) meeting our eligibility criteria. In met

SUBMITTER: Papadopoulos A 

PROVIDER: S-EPMC7341009 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature