Diagnostic value of biopsy sampling in predicting histology in patients with diffuse malignant pleural mesothelioma.

ABSTRACT:

Background

The classification of diffuse malignant mesothelioma into epithelioid, biphasic, and sarcomatoid types is based on histologic patterns. The diagnosis is made on biopsies, and because of intratumoral heterogeneity, they may not be representative of the entire tumor. The number and volume of biopsies needed to reach diagnostic accuracy in diffuse malignant mesothelioma and their prognostic value remain unclear.

Methods

This study examined 759 consecutive patients with pleural diffuse malignant mesothelioma treated by pleurectomy/decortication or extrapleural pneumonectomy for the presence of epithelioid and/or sarcomatoid histology and classified both the presurgery biopsies (core-needle or thoracoscopic) and surgical resection specimens. The number and volume of bi

SUBMITTER: Chirieac LR 

PROVIDER: S-EPMC7341068 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature