Tissue Factor-Targeted ImmunoPET Imaging and Radioimmunotherapy of Anaplastic Thyroid Cancer.

ABSTRACT: Anaplastic thyroid cancer (ATC) is the most aggressive subtype of thyroid cancers with a dismal prognosis. It is aimed to explore a new biomarker and devise a marker-dependent theranostic pair for ATC. Flow cytometry is used to determine tissue factor (TF) expression in thyroid cancer cell lines. ALT-836, a TF-specific monoclonal antibody, is radiolabeled with ⁶⁴Cu to develop ⁶⁴Cu-NOTA-ALT-836. The diagnostic utility is assessed by immuno-positron emission tomography (immunoPET) imaging in ATC models. To facilitate total surgical removal of orthotopic ATCs, a near-infrared fluorescent imaging probe IRDye 800CW-ALT-836 is designed. As the therapeutic component, ¹³¹I-ALT-836 is further developed and the radioimmunotherapy (RIT) efficacy of this agent is inter

SUBMITTER: Wei W 

PROVIDER: S-EPMC7341097 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature