The Gene scb-1 Underlies Variation in Caenorhabditis elegans Chemotherapeutic Responses.

ABSTRACT: Pleiotropy, the concept that a single gene controls multiple distinct traits, is prevalent in most organisms and has broad implications for medicine and agriculture. The identification of the molecular mechanisms underlying pleiotropy has the power to reveal previously unknown biological connections between seemingly unrelated traits. Additionally, the discovery of pleiotropic genes increases our understanding of both genetic and phenotypic complexity by characterizing novel gene functions. Quantitative trait locus (QTL) mapping has been used to identify several pleiotropic regions in many organisms. However, gene knockout studies are needed to eliminate the possibility of tightly linked, non-pleiotropic loci. Here, we use a panel of 296 recombinant inbred advanced intercross lines of C

SUBMITTER: Evans KS 

PROVIDER: S-EPMC7341127 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature