Linkage Disequilibrium-Based Inference of Genome Homology and Chromosomal Rearrangements Between Species.

ABSTRACT: The aim of this study was to analyze the genomic homology between cattle (Bos taurus) and buffaloes (Bubalus bubalis) and to propose a rearrangement of the buffalo genome through linkage disequilibrium analyses of buffalo SNP markers referenced in the cattle genome assembly and also compare it to the buffalo genome assembly. A panel of bovine SNPs (single nucleotide polymorphisms) was used for hierarchical, non-hierarchical and admixture cluster analyses. Thus, the linkage disequilibrium information between markers of a specific panel of buffalo was used to infer chromosomal rearrangement. Haplotype diversity and imputation accuracy of the submetacentric chromosomes were also analyzed. The genomic homology between the species enabled us to use the bovine genome assembly to re

SUBMITTER: de Abreu Santos DJ 

PROVIDER: S-EPMC7341147 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature