Association Between Antenatal Exposure to Zika Virus and Anatomical and Neurodevelopmental Abnormalities in Children.

ABSTRACT:

Importance

Zika virus (ZIKV) is a mosquito-borne flavivirus recognized as teratogenic since the 2015 to 2016 epidemic. Antenatal ZIKV exposure causes brain anomalies, yet the full spectrum has not been delineated.

Objective

To characterize the clinical features of ZIKV infection at a pediatric referral center in Rio de Janeiro, Brazil, among children with antenatal ZIKV exposure.

Design, setting, and participants

Retrospective cohort study conducted from May to July 2019 of a prospective cohort of 296 infants with antenatal ZIKV exposure followed up since December 2015 at a tertiary maternity-pediatric hospital.

Exposures

Zika virus infection during pregnancy.

Main outcomes and measures

Characterization of clinical features with anthropometric, neurologi

SUBMITTER: Cranston JS 

PROVIDER: S-EPMC7341180 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature