Emerging atypicalities in functional connectivity of language-related networks in young infants at high familial risk for ASD.

ABSTRACT: Prior studies have demonstrated that infants and toddlers who later go on to develop autism spectrum disorder (ASD) show atypical functional connectivity as well as altered neural processing of language and other auditory stimuli, but the timeline underlying the emergence of these altered developmental trajectories is still unclear. Here we used resting-state fMRI (rsfMRI) during natural sleep to examine the longitudinal development of functional connectivity in language-related networks from 1.5 to 9 months of age. We found that functional connectivity of networks that underlie the integration of sensory and motor representations, which is crucial for language development, is disrupted in infants at high familial risk (HR) for developing ASD as early as 1.5 months of age. By 9 months of a

SUBMITTER: Liu J 

PROVIDER: S-EPMC7341340 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature