Assessment of 18F-PI-2620 as a Biomarker in Progressive Supranuclear Palsy.

ABSTRACT:

Importance

Progressive supranuclear palsy (PSP) is a 4-repeat tauopathy. Region-specific tau aggregates establish the neuropathologic diagnosis of definite PSP post mortem. Future interventional trials against tau in PSP would strongly benefit from biomarkers that support diagnosis.

Objective

To investigate the potential of the novel tau radiotracer 18F-PI-2620 as a biomarker in patients with clinically diagnosed PSP.

Design, setting, and participants

In this cross-sectional study, participants underwent dynamic 18F-PI-2620 positron emission tomography (PET) from 0 to 60 minutes after injection at 5 different centers (3 in Germany, 1 in the US, and 1 in Australia). Patients with PSP (including those with Richardson syndrome [RS]) according to Movement Disorder Society

SUBMITTER: Brendel M 

PROVIDER: S-EPMC7341407 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature