Clinical efficacy and safety in patients treated with teicoplanin with a target trough concentration of 20 μg/mL using a regimen of 12 mg/kg for five doses within the initial 3 days.

ABSTRACT:

Background

A trough concentration (C_min) ≥20 μg/mL of teicoplanin is recommended for the treatment of serious methicillin-resistant Staphylococcus aureus (MRSA) infections. However, sufficient clinical evidence to support the efficacy of this target C_min has not been obtained. Even though the recommended high C_min of teicoplanin was associated with better clinical outcome, reaching the target concentration is challenging.

Methods

Pharmacokinetics and adverse events were evaluated in all eligible patients. For clinical efficacy, patients who had bacteremia/complicated MRSA infections were analyzed. The primary endpoint for clinical efficacy was an early clinical response at 72-96 h after the start of therapy. Five dosed of 12 mg/kg or 10 mg/kg

SUBMITTER: Ueda T 

PROVIDER: S-EPMC7341468 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature