UVB Irradiation Induced Cell Damage and Early Onset of Junbb Expression in Zebrafish.

ABSTRACT: Ultraviolet B (UVB) radiation has drawn more attention over these past few decades since it causes severe DNA damage and induces inflammatory response. Serial gene profiling and high throughput data in UVB-associated phenomenon in human cultured cells or full rack of human skin have been investigated. However, results using different tissue models lead to ambiguity in UVB-induced pathways. In order to systematically understand the UVB-associated reactions, the zebrafish model was used, and whole organism gene profiling was performed to identify a novel biomarker which can be used to generate a new mechanistic approach for further screening on a UVB-related system biology. In this study, detailed morphological assays were performed to address biological response after receiving UVB irradiat

SUBMITTER: Chen RY 

PROVIDER: S-EPMC7341518 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature