Factors associated with refractory autoimmune necrotizing myopathy with anti-signal recognition particle antibodies.

ABSTRACT:

Background

Autoimmune necrotizing myopathy with anti-signal recognition particle antibodies (ANM-SRP) is regarded as refractory myositis, whereby some patients respond poorly to conventional immunosuppression and require B cell depletion treatment. This study aimed to evaluate factors associated with refractory ANM-SRP.

Results

Clinical and pathological data from 48 patients with ANM-SRP were collected. We followed up clinical symptoms and image changes over 12 months. Univariate and multivariate analyses were undertaken to determine the associations between variables of interest and poor response to therapy. Refractory ANM-SRP appeared in 32.5% of patients who showed no or minimal improvement after 12 months of steroid therapy. The clinical risk factors for refractory patie

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC7341563 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature