Cumulative inactivated vaccine exposure and allergy development among children: a birth cohort from Japan.

ABSTRACT: BACKGROUND:Adjuvants used in inactivated vaccines often upregulate type 2 immunity, which is dominant in allergic diseases. We hypothesised that cumulative adjuvant exposure in infancy may influence the development of allergies later in life by changing the balance of type 1/type 2 immunity. We examined the relationship between immunisation with different vaccine types and later allergic disease development. METHODS:We obtained information regarding vaccinations and allergic diseases through questionnaires that were used in The Japan Environment and Children's Study (JECS), which is a nationwide, multicentre, prospective birth cohort study that included 103,099 pregnant women and their children. We examined potential associations between the initial vaccination before 6 months of age and s

SUBMITTER: Yamamoto-Hanada K 

PROVIDER: S-EPMC7341599 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature