Mitochondrial GWAS and association of nuclear - mitochondrial epistasis with BMI in T1DM patients.

ABSTRACT:

Background

BMI is a strong indicator of complications from type I diabetes, especially under intensive treatment.

Methods

We have genotyped 435 type 1 diabetics using Illumina Infinium Omni Express Exome-8 v1.4 arrays and performed mitoGWAS on BMI. We identified additive interactions between mitochondrial and nuclear variants in genes associated with mitochondrial functioning MitoCarta2.0 and confirmed and refined the results on external cohorts: the Framingham Heart Study (FHS) and GTEx data. Linear mixed model analysis was performed using the GENESIS package in R/Bioconductor.

Results

We find a borderline significant association between the mitochondrial variant rs28357980, localized to MT-ND2, and BMI (β = - 0.69, p = 0.056). This BMI association was confirmed on 1

SUBMITTER: Ludwig-Slomczynska AH 

PROVIDER: S-EPMC7341625 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature