Measuring vaccine effectiveness against persistent HPV infections: a comparison of different statistical approaches.

ABSTRACT:

Background

Persistent high-risk human papillomavirus (HPV) infection is endorsed by the World Health Organization as an intermediate endpoint for evaluating HPV vaccine effectiveness/efficacy. There are different approaches to estimate the vaccine effectiveness/efficacy against persistent HPV infections.

Methods

We performed a systematic literature search in Pubmed to identify statistical approaches that have been used to estimate the vaccine effectiveness/efficacy against persistent HPV infections. We applied these methods to data of a longitudinal observational study to assess their performance and compare the obtained vaccine effectiveness (VE) estimates.

Results

Our literature search identified four approaches: the conditional exact test for comparing two independ

SUBMITTER: Donken R 

PROVIDER: S-EPMC7341660 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature