Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study.

ABSTRACT:

Background

One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phenotypes are scarce, relative to studies of other cognitive traits and neurodevelopmental phenotypes. Moreover, most genetic studies examining such phenotypes do not incorporate parent-of-origin effects, which could account for some of the heritability of the investigated trait. We performed a genome-wide association study of receptive language, examining both child genetic effects and parent-of-origin effects.

Results

Using a family-based cohort with 400 children with receptive language scores, we found a genome-wide significant paternal parent-of-origin effec

SUBMITTER: Nudel R 

PROVIDER: S-EPMC7341668 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature