JAK-STAT Activity in Peripheral Blood Cells and Kidney Tissue in IgA Nephropathy.

ABSTRACT:

Background and objectives

IgA nephropathy is the most common primary glomerular disease in the world. Marked by mesangial inflammation and proliferation, it generally leads to progressive kidney fibrosis. As the Janus kinase signal transducer and activator of transcription pathway has been implicated as an important mediator of diabetic kidney disease and FSGS, detailed investigation of this pathway in IgA nephropathy was undertaken to establish the basis for targeting this pathway across glomerular diseases.

Design, setting, participants, & measurements

Well characterized patients with IgA nephropathy and controls were studied, allowing us to compare 77 patients with biopsy-proven IgA nephropathy with 45 healthy subjects. STAT phosphorylation was assessed in peripheral bloo

SUBMITTER: Tao J 

PROVIDER: S-EPMC7341773 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature