Impact of HPV vaccination on cervical screening performance: a population-based cohort study.

ABSTRACT:

Background

Human papillomavirus (HPV) vaccination is predicted to lower the positive predictive value (PPV) of cytology.

Methods

We included 153,250 girls born between 1989 and 1993, resident in Sweden since the introduction of HPV vaccines (October 2006) and attending cervical screening at age 23 years. We assessed their first cytology and following histopathological diagnosis using Swedish National Cervical Screening Registry (NKCx). By linkage with the national Swedish HPV vaccination registry, we determined PPV of abnormal cytology for cervical intraepithelial neoplasia grade 2 or worse (CIN2+) and the differences with 95% confidence intervals (CIs) according to vaccination status.

Results

The PPV of high-grade cytology for CIN2+ was 69.9% (95% CI, 67.9-71.9), 64.

SUBMITTER: Lei J 

PROVIDER: S-EPMC7341799 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature