Sleep in unnatural times: illuminated night negatively affects sleep and associated hypothalamic gene expressions in diurnal zebra finches.

ABSTRACT: We investigated the effects of exposure at ecologically relevant levels of dim light at night (dLAN) on sleep and the 24 h hypothalamic expression pattern of genes involved in the circadian timing (per2, bmal1, reverb-β, cry1, ror-α, clock) and sleep regulatory pathways (cytokines: tlr4, tnf-α, il-1β, nos; Ca²⁺-dependent pathway: camk2, sik3, nr3a; cholinergic receptor, achm3) in diurnal female zebra finches. Birds were exposed to 12 h light (150 lux) coupled with 12 h of absolute darkness or of 5 lux dim light for three weeks. dLAN fragmented the nocturnal sleep in reduced bouts, and caused sleep loss as evidenced by reduced plasma oxalate levels. Under dLAN, the 24 h rhythm of

SUBMITTER: Batra T 

PROVIDER: S-EPMC7341939 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature