Discovery of Lipidome Alterations Following Traumatic Brain Injury via High-Resolution Metabolomics.

ABSTRACT: Traumatic brain injury (TBI) can occur across wide segments of the population, presenting in a heterogeneous manner that makes diagnosis inconsistent and management challenging. Biomarkers offer the potential to objectively identify injury status, severity, and phenotype by measuring the relative concentrations of endogenous molecules in readily accessible biofluids. Through a data-driven, discovery approach, novel biomarker candidates for TBI were identified in the serum lipidome of adult male Sprague-Dawley rats in the first week following moderate controlled cortical impact (CCI). Serum samples were analyzed in positive and negative modes by ultraperformance liquid chromatography-mass spectrometry (UPLC-MS). A predictive panel for the classification of injured and uninjured sera samples

SUBMITTER: Hogan SR 

PROVIDER: S-EPMC7341947 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature