Sustained Improvement of Negative Self-Schema After a Single Ketamine Infusion: An Open-Label Study.

ABSTRACT: Conventional antidepressants have several important limitations, including a lack of direct effects on negative self-schema, which is at the core of Beck's cognitive theory of depression. Based on previous studies showing a positive effect of ketamine on negative cognition, we compared reductions in negative self-schema between responders and non-responders to a single infusion of ketamine. In an open-label study, 26 participants with treatment-resistant depression received 0.5 mg/kg ketamine via infusion. Depression symptoms were assessed at baseline, 24 h, and 7 days after treatment with Montgomery-Åsberg Depression Rating Scale (MADRS) and Beck Depression Inventory (BDI-II). Nine of the 26 participants fulfilled response criteria after 24 h. Of these, eight still fulfilled response crit

SUBMITTER: Hasler G 

PROVIDER: S-EPMC7341975 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature