Tissue Mechanics Regulate Mitotic Nuclear Dynamics during Epithelial Development.

ABSTRACT: Cell divisions are essential for tissue growth. In pseudostratified epithelia, where nuclei are staggered across the tissue, each nucleus migrates apically before undergoing mitosis. Successful apical nuclear migration is critical for planar-orientated cell divisions in densely packed epithelia. Most previous investigations have focused on the local cellular mechanisms controlling nuclear migration. Inter-species and inter-organ comparisons of different pseudostratified epithelia suggest global tissue architecture may influence nuclear dynamics, but the underlying mechanisms remain elusive. Here, we use the developing Drosophila wing disc to systematically investigate, in a single epithelial type, how changes in tissue architecture during growth influence mitotic nuclear migration. We obse

SUBMITTER: Kirkland NJ 

PROVIDER: S-EPMC7342018 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature