Aflatoxin B₁ exposure and liver cirrhosis in Guatemala: a case-control study.

ABSTRACT:

Objective

In Guatemala, cirrhosis is among the 10 leading causes of death, and mortality rates have increased lately. The reasons for this heavy burden of disease are not clear as the prevalence of prominent risk factors, such as hepatitis B virus, hepatitis C virus and heavy alcohol consumption, appears to be low. Aflatoxin B₁ (AFB₁) exposure, however, appears to be high, and thus could be associated with the high burden of cirrhosis. Whether AFB₁ increases the risk of cirrhosis in the absence of viral infection, however, is not clear.

Design

Cirrhosis cases (n=100) from two major referral hospitals in Guatemala City were compared with controls (n=200) from a cross-sectional study. Logistic regression was used to estimate the ORs and 95% CIs

SUBMITTER: Alvarez CS 

PROVIDER: S-EPMC7342465 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature