Relationship between high-density lipoprotein cholesterol levels and endothelial function in women: a cross-sectional study.

ABSTRACT:

Objectives

The purpose of this study was to evaluate the relationship between high-density lipoprotein cholesterol (HDL-C) levels and endothelial function in women.

Design

Cross-sectional study.

Setting

22 university hospitals and affiliated clinics in Japan.

Participants

1719 Japanese women aged 17-90 years who were not receiving lipid-lowering therapy.

Measures

We evaluated flow-mediated vasodilation (FMD) and serum levels of HDL-C. All participants were divided into four groups by HDL-C level: low HDL-C (<40 mg/dL), moderate HDL-C (40-59 mg/dL), high HDL-C (60-79 md/dL) and extremely high HDL-C (≥80 mg/dL).

Results

Univariate regression analysis revealed a significant relationship between FMD and HDL-C (r=0.12, p<0.001). FMD values were signifi

SUBMITTER: Takaeko Y 

PROVIDER: S-EPMC7342861 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature