Dataset Information

Relationship between high-density lipoprotein cholesterol levels and endothelial function in women: a cross-sectional study.

ABSTRACT:

Objectives

The purpose of this study was to evaluate the relationship between high-density lipoprotein cholesterol (HDL-C) levels and endothelial function in women.

Design

Cross-sectional study.

Setting

22 university hospitals and affiliated clinics in Japan.

Participants

1719 Japanese women aged 17-90 years who were not receiving lipid-lowering therapy.

Measures

We evaluated flow-mediated vasodilation (FMD) and serum levels of HDL-C. All participants were divided into four groups by HDL-C level: low HDL-C (<40 mg/dL), moderate HDL-C (40-59 mg/dL), high HDL-C (60-79 md/dL) and extremely high HDL-C (≥80 mg/dL).

Results

Univariate regression analysis revealed a significant relationship between FMD and HDL-C (r=0.12, p<0.001). FMD values were significantly smaller in the low HDL-C group (5.2%±3.8%) and moderate HDL-C group (5.2%±3.8%) than in the extremely high HDL-C group (6.7%±3.4%) (p=0.024 and p=0.003, respectively), while there was no significant difference in FMD between the high HDL-C group and the extremely high HDL-C group. Multiple logistic regression analysis did not show a significant association between HDL-C levels and FMD.

Conclusions

Endothelial function increased in relation to HDL-C levels. However, there was no association of HDL-C levels with endothelial function after adjustment of traditional cardiovascular risk factors in women.

Trial registration number

UMIN000012950; Results.

SUBMITTER: Takaeko Y

PROVIDER: S-EPMC7342861 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Relationship between high-density lipoprotein cholesterol levels and endothelial function in women: a cross-sectional study.

Takaeko Yuji Y Matsui Shogo S Kajikawa Masato M Maruhashi Tatsuya T Yamaji Takayuki T Harada Takahiro T Han Yiming Y Hashimoto Haruki H Kihara Yasuki Y Hida Eisuke E Chayama Kazuaki K Goto Chikara C Aibara Yoshiki Y Yusoff Farina Mohamad FM Kishimoto Shinji S Nakashima Ayumu A Higashi Yukihito Y

BMJ open 20200707 7

<h4>Objectives</h4>The purpose of this study was to evaluate the relationship between high-density lipoprotein cholesterol (HDL-C) levels and endothelial function in women.<h4>Design</h4>Cross-sectional study.<h4>Setting</h4>22 university hospitals and affiliated clinics in Japan.<h4>Participants</h4>1719 Japanese women aged 17-90 years who were not receiving lipid-lowering therapy.<h4>Measures</h4>We evaluated flow-mediated vasodilation (FMD) and serum levels of HDL-C. All participants were div ...[more]

PMID: 32641366

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Dataset Information

Relationship between high-density lipoprotein cholesterol levels and endothelial function in women: a cross-sectional study.

Objectives

Design

Setting

Participants

Measures

Results

Conclusions

Trial registration number

Publications

Relationship between high-density lipoprotein cholesterol levels and endothelial function in women: a cross-sectional study.

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