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Oxygenated Cyclohexene Derivatives and Other Constituents from the Roots of Monanthotaxis trichocarpa.

ABSTRACT: Three new oxygenated cyclohexene derivatives, trichocarpeols A (1), B (2), and C (3), along with nine known secondary metabolites, were isolated from the methanolic root extract of Monanthotaxis trichocarpa. They were identified by NMR spectroscopic and mass spectrometric analyses, and the structure of trichocarpeol A (1) was confirmed by single-crystal X-ray diffraction. Out of the 12 isolated natural products, uvaretin (4) showed activity against the Gram-positive bacterium Bacillus subtilis with a MIC value of 18 μM. None of the isolated metabolites was active against the Gram-negative Escherichia coli at a ∼5 mM (2000 μg/mL) concentration. Whereas 4 showed cytotoxicity at EC₅₀ 10.2 μM against the MCF-7 human breast cancer cell line, the other compounds were inactive or not tested.

SUBMITTER: Maeda G

PROVIDER: S-EPMC7343284 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Oxygenated Cyclohexene Derivatives and Other Constituents from the Roots of Monanthotaxis trichocarpa.

Maeda Gasper G van der Wal Jelle J Gupta Arvind Kumar AK Munissi Joan J E JJE Orthaber Andreas A Sunnerhagen Per P Nyandoro Stephen S SS Erdélyi Máté M

Journal of natural products 20200127 2

Three new oxygenated cyclohexene derivatives, trichocarpeols A (1), B (2), and C (3), along with nine known secondary metabolites, were isolated from the methanolic root extract of Monanthotaxis trichocarpa. They were identified by NMR spectroscopic and mass spectrometric analyses, and the structure of trichocarpeol A (1) was confirmed by single-crystal X-ray diffraction. Out of the 12 isolated natural products, uvaretin (4) showed activity against the G ...[more]

PMID: 31986029

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