Prenatal alcohol exposure and sleep-wake behaviors: exploratory and naturalistic observations in the clinical setting and in an animal model.

ABSTRACT:

Introduction

Clinical research and studies using animal models have revealed a complex and relatively under-explored interaction between prenatal alcohol exposure (PAE) and alterations in sleep-wake behaviors.

Objectives

To utilize a structured naturalistic observation-based methodology, consisting of descriptive elements, to provide insight into possible links between altered sleep and disruptive daytime presentations in children and adolescents with fetal alcohol spectrum disorder (FASD). To apply a similar structured behavioral observation protocol in a PAE animal model to compare outcomes from the experimental and clinical studies utilizing naturalistic observational methodology.

Methods

Forty pediatric patients with FASD (1.8-17.5 yrs, median age 9.4 yrs) and chr

SUBMITTER: Ipsiroglu OS 

PROVIDER: S-EPMC7343292 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature