Host and Parasite Transcriptomic Changes upon Successive Plasmodium falciparum Infections in Early Childhood.

ABSTRACT: Children are highly susceptible to clinical malaria, and in regions where malaria is endemic, their immune systems must face successive encounters with Plasmodium falciparum parasites before they develop immunity, first against severe disease and later against uncomplicated malaria. Understanding cellular and molecular interactions between host and parasites during an infection could provide insights into the processes underlying this gradual acquisition of immunity, as well as to how parasites adapt to infect hosts that are successively more malaria experienced. Here, we describe methods to analyze the host and parasite gene expression profiles generated simultaneously from blood samples collected from five consecutive symptomatic P. falciparum infections in three Malian chi

SUBMITTER: Bradwell KR 

PROVIDER: S-EPMC7343306 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature